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12th International Conference on Tissue Engineering and Regenerative Medicine , will be organized around the theme “Examine Regenerative Therapy towards Overhaul Revive & Recommence”
Tissue Science 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Tissue Science 2018
Submit your abstract to any of the mentioned tracks.
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Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. Tissue engineering involves the use of a scaffold for the formation of new viable tissue for a medical purpose. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own. While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.
- Track 1-1Musculoskeletal tissue regeneration
- Track 1-2Cardiovascular tissue regeneration
- Track 1-3In-situ tissue regeneration
- Track 1-4Tissue bio markers
- Track 1-5Tissue graft tolerance
- Track 1-6Tissue mechanics and mechanobiology
Regenerative medicine is the branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues. Regenerative medicine includes the generation and use of therapeutic stem cells, tissue engineering and the production of artificial organs. Regenerative medicine seeks to replace tissue or organs that have been damaged by disease, trauma, or congenital issues, vs. the current clinical strategy that focuses primarily on treating the symptoms. The tools used to realize these outcomes are tissue engineering, cellular therapies, and medical devices and artificial organs
- Track 2-1Medical Devices and Artificial Organs
- Track 2-2Advanced developments in artificial organ system
- Track 2-3Organ transplantation and its new techniques
- Track 2-4Vascular tissue engineering and regeneration
- Track 2-5Recent innovations in regenerative and tissue engineering
- Track 2-6Advancements in biomedical and tissue engineering techniques
- Track 2-7Periodontal therapy/surgery
- Track 2-8Prosthodontics and endodontics
- Track 2-9Clinical Translation
- Track 2-10Regenerating a new kidney
- Track 2-11Cellular Therapies
- Track 2-12Regenerative-medicine approach
The fields of Tissue Engineering and 3D-Bioprinting are important for ultimately realizing the full potential of regenerative medicine. The potential to "3D-print" tissues and organs is gaining extensive interest and this conference brings together the academic as well as industry stakeholders in these expanding fields.
From a technology/methodology perspective, this conference addresses Tissue Engineering as well as Bio fabrication and Bio printing as we explore the latest developments in this field. Indeed, the field of Synthetic Biology currently with many ramifications and application areas is an important component of the broader Bio fabrication space and therefore an entire conference track is devoted to this expanding field. There will be a session focusing on the Clinical Translation of Tissue Engineering as means to provide a Current State of the Landscape and Trajectory for the Future. Posters from delegates are welcomed as a means to disseminate the most up-to-date research and commercial applications which complement the presentations from the leaders in these fields. A co-located exhibition brings forth the technologies and commercial products in the Tissue Engineering, 3D-Bioprinting and Bio fabrication fields and features companies large and small.
- Track 3-13D Printing for Life science
- Track 3-2Material consideration for 3D Printing in Tissue Engineering
- Track 3-3Importance of 3D Bio printing
The recent integration of emerging nanotechnology into biology and biomedicine has resulted in a range of innovative Nano engineering efforts for the repair and regeneration of tissues and organs. Thus, it is expected that Nano engineering approaches to biomedical applications can contribute to addressing the present issue of personal and global health care and its economic burden for more than 7 billion people. Biomimetic Nano patterns alone can direct the differentiation of stem cells without involvement of exogenous soluble biochemical factors. This regulation of cellular behaviour by nanotechnology is one of many examples demonstrating the significant applications of Nano engineering in biomedicine. This special issue includes four review papers and seven research articles that provide an insight into current Nano engineering approaches to the repair or regeneration of tissues and organs
- Track 4-1Nano particle-cell interactions
- Track 4-2Nanotechnology in the Regeneration of Complex Tissues
- Track 4-3Effects of guided tissue regeneration
Tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells.
As a source of the new bioengineered teeth somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolyme in the shape of the new tooth .
Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell. Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity. Second, under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions. In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.
- Track 6-1Embryonic stem (ES) cells
- Track 6-2 Adult stem cell
- Track 6-3Induced Pluripotent Stem Cells
- Track 6-4Tissue stem cells
- Track 6-5Application of stem cell
- Track 6-6Stem Cell Transplantation
Biomedical engineering is the application of engineering principles in designing techniques and technology to medicine and biology for healthcare purposes. This field link the gap between engineering and medicine, combining the design and problem solving skills of engineering with medical and biological sciences to advance health care treatment, including diagnosis, monitoring, and therapeutics. The field transitions from being an interdisciplinary specialization among already-established fields enhance the impact of health care. Biomedical techniques on tissue science and regenerative medicine are computer modelling, Tissue Mechanics, Bio patterning technology, Bio-inspired Computing to promote tissue regeneration.
Tissue repair and regeneration following injury or disease are often thought to recapitulate embryonic development by using similar molecular and cellular pathways. In addition, many embryonic tissues, such as the spinal cord, heart, and limbs, have some regenerative potential and may utilize mechanisms that can be exogenously activated in adult tissues. For example, BMP signalling regulates nervous system development, and SMAD reactivation plays a critical role in adult nerve regeneration and repair in animal models of spinal cord injury. While similar molecular pathways are utilized during embryogenesis and adult tissue regeneration, recent reports suggest the mechanisms by which these developmental programs are reactivated and maintained may vary in adult tissues. Adult fish and amphibians have a remarkable capacity for tissue regeneration, while mammals have a limited regenerative capacity.
- Track 8-1Dental tissue repair
- Track 8-2Deregulation of normal tissue repair
- Track 8-3Effects of guided tissue regeneration
- Track 8-4Organ-Specific Regeneration
- Track 8-5Cancer, Skin, and the Wound Healing Analogy
- Track 8-6Epigenetics
Bioengineered skin and soft tissue substitutes may be derived from human tissue (autologous or allogeneic), nonhuman tissue (xenographic), synthetic materials, or a composite of these materials. Bioengineered skin and soft tissue substitutes are being evaluated for a variety of conditions, including breast reconstruction and healing lower-extremity ulcers and severe burns. Acellular dermal matrix (ADM) products are also being evaluated for soft tissue repair.
This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have been also aiming at replacing lost or severely damaged tissues or organs. Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for organ transplantation with soft tissues. Although significant progress has been made in the tissue engineering field, many challenges remain and further development in this area will require on-going interactions and collaborations among the scientists from multiple disciplines, and in partnership with the regulatory and the funding agencies. As a result of the medical and market potential, there is significant academic and corporate interest in this technology.
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.
- Track 11-1Development of regenerative treatment models
- Track 11-2Sources of stem cells
- Track 11-3 Stem cells and hard-tissue repair
- Track 11-4Stem cells and orthopedic repairs
- Track 11-5Application of stem cell therapy
There are more than 200 types of cancer, including Breast cancer, skin cancer, lung cancer, colon cancer, Prostate cancer, and lymphoma. Symptoms and Treatment varies depending on the type of Cancer. Some people with cancer will have only one treatment. But most people have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy. The Anticancer therapies include surgical therapy, Chemotherapy, Adjuvant therapy, Neoadjuvant therapy, Palliative therapy, Immunotherapy, Hormonal therapy, Radiotherapy, Nutritional therapy, Phototherapy. Phototherapy / proton beam therapy is the most advanced among all the therapies. All Anticancer agents act by disturbing cell multiplication or normal functioning, DNA synthesis or chromosomal migration, and by blocking or changing RNA and protein metabolism.
- Track 12-1Histopathology
- Track 12-2Tissue bio markers
- Track 12-3Tissue bio markers
- Track 12-4Photo dynamic therapy
- Track 12-5Tissue graft tolerance
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumours are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements.While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.
- Track 13-1Surgical Therapy
- Track 13-2Chemotherapy
- Track 13-3Radiation Therapy
- Track 13-4Cancer Genetics
- Track 13-5Cancer Immunotherapy
Tissue engineering of musculoskeletal tissues, particularly bone and cartilage, is a rapidly advancing field. In bone, technology has centred on bone graft substitute materials and the development of biodegradable scaffolds. Recently, tissue engineering strategies have included cell and gene therapy. The availability of growth factors and the expanding knowledge base concerning the bone regeneration with modern techniques like recombinant signalling molecules, solid free form fabrication of scaffolds, synthetic cartilage, Electrochemical deposition, spinal fusion and ossification are new generated techniques for tissue-engineering applications. The worldwide market for bone cartilage repairs strategies is estimated about $300 million. During the last 10/15 years, the scientific community witnessed and reported the appearance of several sources of stem cells with both osteon and chondrogenic potential.
- Track 14-1Bone regeneration and modern techniques
- Track 14-2Recombinant signalling molecules
- Track 14-3Solid free form fabrication of scaffolds
- Track 14-4Spinal fusion and Ossification
- Track 14-5Using stem cells to build new bones
Bioreactors come in a variety of sizes, shapes, and forms. Single-use bioreactors for cell culture were introduced to the market in the mid-90s and they are now widely used in process development, research, and manufacturing up to 2000 L scale. Disposable technology brings an increased speed and flexibility to bioprocessing and decreases cleaning validation costs.
In vitro cell models are invaluable tools for studying diseases and discovering drugs. Human induced pluripotent stem cells, particularly derived from patients, are an advantageous resource for generating ample supplies of cells to create unique platforms that model disease. This manuscript will review recent developments in modeling a variety of diseases (including their cellular phenotypes) with induced pluripotent stem cells derived from patients. It will also describe how researchers have exploited these models to validate drugs as potential therapeutics for these devastating diseases
Gene therapy aims to transfer genetic material into cells to provide them with new functions. A gene transfer agent has to be safe, capable of expressing the desired gene for a sustained period of time in a sufficiently large population of cells to produce a biological effect. Identifying a gene transfer tool that meets all of these criteria has proven to be a difficult objective. Viral and no viral vectors, in vivo, ex vivo and in situ strategies co-exist at present, although ex vivo lenti-or retroviral vectors are presently the most popular. Natural stem cells (from embryonic, hematopoietic, mesenchymal, or adult tissues) or induced progenitor stem (iPS) cells can be modified by gene therapy for use in regenerative medicine.
- Track 17-1In-vivo gene transfer
- Track 17-2Ex-vivo gene transfer
- Track 17-3Gene doping
- Track 17-4Application of gene therapy
- Track 17-5Allogeneic Cell Therapy
- Track 17-6Human embryonic stem cells
- Track 17-7Mesenchymal Stem Cell Therapy
Embryonic stem cells are pluripotent, meaning they are able to grow (i.e. differentiate) into all derivatives of the three primary germ layers: ectoderm, endoderm and mesoderm. In other words, they can develop into each of the more than 200 cell types of the adult body as long as they are specified to do so. Embryonic stem cells are distinguished by two distinctive properties: their pluripotency, and their ability to replicate indefinitely. ES cells are pluripotent, that is, they are able to differentiate into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. These include each of the more than 220 cell types in the adult body. Pluripotency distinguishes embryonic stem cells from adult stem cells found in adults; while embryonic stem cells can generate all cell types in the body, adult stem cells are multipotent and can produce only a limited number of cell types. Additionally, under defined conditions, embryonic stem cells are capable of propagating themselves indefinitely. This allows embryonic stem cells to be employed as useful tools for both research and regenerative medicine, because they can produce limitless numbers of themselves for continued research or clinical use.
- Track 18-1Pro embryonic stem cell research
- Track 18-2Human embryonic stem cells
The tremendous need for bone tissue in numerous clinical situations and the limited availability of suitable bone grafts are driving the development of tissue engineering approaches to bone repair. In order to engineer viable bone grafts, one needs to understand the mechanisms of native bone development and fracture healing, as these processes should ideally guide the selection of optimal conditions for tissue culture and implantation. Engineered bone grafts have been shown to have capacity for osteogenesis, osteoconduction, osteoinduction and osteointegration - functional connection between the host bone and the graft. Cells from various anatomical sources in conjunction with scaffolds and osteogenic factors have been shown to form bone tissue in vitro. The use of bioreactor systems to culture cells on scaffolds before implantation further improved the quality of the resulting bone grafts. Animal studies confirmed the capability of engineered grafts to form bone and integrate with the host tissues.
- Track 19-1 Principles of Bone and Cartilage Reconstruction
- Track 19-2Cell sources for bone and cartilage tissue engineering
- Track 19-3Osteogenic signaling factors
- Track 19-4Chondrogenic signaling factors
- Track 19-5Design and fabrication of 3-D scaffold
- Track 19-6Using stem cells to build new bones
Tissue engineering along with regenerative medicine can be used to create ‘Scaffolds’ in the human body. These scaffolds are used to support organs and organ systems that may have been damaged after injury or disease. So what is tissue engineering? ‘Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physico-chemical factors to improve or replace biological functions’. This is most commonly achieved through the use of stem cells. Stem cells are unique types of cells that are undifferentiated. So the main focus of creating these constructs is to be able to safely deliver these stem cells, and create a structure that is physically and mechanically stable so that these stem cells can differentiate. Scaffolds are of great importance in clinical medicine. It is an upcoming field, and usually associated with conditions involving organ disease or failure. It is used to rebuild organs and return normal function.
- Track 20-1Scaffold designs
- Track 20-2Fabrication of scaffolds
- Track 20-3Biodegradable nano fiber scaffolds
- Track 20-4D scaffolds and models
- Track 20-5Surface ligands and molecular architecture
- Track 20-6Porous scaffolds